反应详情

To a stirred solution of methyl 2-(2-fluorophenyl)cyclopropanecarboxylate (4.8 g, 24.72 mmol) in tetrahydrofuran (25 mL), was added 10M sodium hydroxide solution (approximately 2 mL), a small amount of water, and sufficient methanol to achieve a homogeneous reaction mixture. The reaction mixture was then allowed to stir at rt for approximately 2 h. After concentrating the reaction mixture, 1N HCl was added until the mixture was acidic. The organic layer was extracted twice with ethyl acetate, then washed with brine, dried over anhydrous Na2SO4, and concentrated to afford the title compound. M.S. (M+1): 181.

1. concentrationAfter concentrating the reaction mixture, 1N HCl
2. additionwas added until the mixture
3. extractionThe organic layer was extracted twice with ethyl acetate
4. washwashed with brine
5. dry with materialdried over anhydrous Na2SO4
6. concentrationconcentrated