o-Fluorobenzaldehyde → 1-fluoro-2-{(E)-2-[4-(phenylsulfonyl)phenyl]vinyl}benzene

HRID 1351653Notes

Reaction equation

HRID 1351653 reaction equation
[C:1]1([S:7]([C:10]2[CH:22]=[CH:21][C:13]([CH2:14]P(=O)(OC)OC)=[CH:12][CH:11]=2)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[F:23][C:24]1[CH:31]=[CH:30][CH:29]=[CH:28][C:25]=1[CH:26]=O>>[F:23][C:24]1[CH:31]=[CH:30][CH:29]=[CH:28][C:25]=1/[CH:26]=[CH:14]/[C:13]1[CH:21]=[CH:22][C:10]([S:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)(=[O:9])=[O:8])=[CH:11][CH:12]=1

Participants

3

Reactant 2

HCID 67970o-FluorobenzaldehydeHCID 15247537Dimethyl[4-(phenylsulfonyl)benzyl]phosphonate

Product 1

HCID 210994011-fluoro-2-{(E)-2-[4-(phenylsulfonyl)phenyl]vinyl}benzene

Procedure

The title compound was prepared from dimethyl [4-(phenylsulfonyl)benzyl]phosphonate (Step 2) and 2-fluorobenzaldehyde according to the method of Example 46 Step 5. δH (500 MHz, CDCl3): 7.97–7.92 (4H, m), 7.63–7.55 (4H, m), 7.52–7.49 (2H, m), 7.35 (1H, d, J=16.5 Hz), 7.30–7.25 (1H, m), 7.18–7.14 (2H, m), 7.10–7.06 (1H, m).

Sources & evidence

ORD record
ord-f38096f10a4c4d018472a7889200f7cd
Source dataset
uspto-grants-2007_05
Patent number
US07217740B2

Reaction notes

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