Methanol → 8-Benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]-2-hydroxyethoxy]-1-phenyl-8-azabicyclo[3.2.1]octane-6-carbonitrile
Reaction equation
[BH4-:44].[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[N:8]1[C:9]2([c:38]3[cH:39][cH:40][cH:41][cH:42][cH:43]3)[CH:10]([O:18][CH:19]([c:20]3[cH:21][c:22]([C:30]([F:31])([F:32])[F:33])[cH:23][c:24]([C:26]([F:27])([F:28])[F:29])[cH:25]3)[C:34](=[O:35])[O:36][CH3:37])[CH2:11][CH2:12][CH:13]1[CH:14]([C:16]#[N:17])[CH2:15]2.[CH3:46][OH:47].[Na+:45]>>[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[N:8]1[C:9]2([c:38]3[cH:39][cH:40][cH:41][cH:42][cH:43]3)[CH:10]([O:18][CH:19]([c:20]3[cH:21][c:22]([C:30]([F:31])([F:32])[F:33])[cH:23][c:24]([C:26]([F:27])([F:28])[F:29])[cH:25]3)[CH2:34][OH:35])[CH2:11][CH2:12][CH:13]1[CH:14]([C:16]#[N:17])[CH2:15]2Participants
5
Reactant 4
Product 1
Sources & evidence
- ORD record
- ord-3fe0ac52475c429b8190e946ed5425dc
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (9/10)
Reaction notes
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