Carbonic acid di-2-pyridyl ester → 1-Amino-3,3-diethoxypropane
Reaction equation
FC(F)(C[CH2:18][CH2:19][N:20]1C(=O)C=CC1=O)C(F)(F)C(F)(C1C=CC=CC=1)C([O-])=O.[C:28](=O)([O:36][C:37]1[CH:42]=CC=CN=1)[O:29][C:30]1[CH:35]=CC=CN=1>C(Cl)Cl.CCOCC>[NH2:20][CH2:19][CH2:18][CH:28]([O:29][CH2:30][CH3:35])[O:36][CH2:37][CH3:42]Participants
5
Reactant 2
Product 1
Reagents, catalysts & solvents 2
Procedure
To 981 mg (3 mmol) of pentafluorophenyl-6-maleimido-hexane-1-carboxylate (1) (Example 11) dissolved in dry methylene chloride (30 ml) was added 10 g (1 mmol) of •-amino-•-amino PEG (2) (MW 10,000, n=226) dissolved in 50 ml of dry methylene chloride. The reaction mixture was stirred at room temperature for 2 h and the product 3 obtained as a white powder by precipitation in ether (100 ml). The product was then dried under vacuum for 4 h.
Sources & evidence
- ORD record
- ord-a79f9ec2e398434fab2559eb6302a09b
- Source dataset
- uspto-grants-2007_05
- Patent number
- US07217845B2
Reaction notes
Loading…