Sodium Hydroxide → HCID 86585781, compound

HRID 1351827Notes

Reaction equation

HRID 1351827 reaction equation
C([O:3][C:4](=[O:33])[CH2:5][O:6][C:7]1[CH:8]=[CH:9][C:10]2[CH2:16][CH2:15][CH2:14][CH:13]([N:17]([C:25]([O:27][C:28]([CH3:31])([CH3:30])[CH3:29])=[O:26])[CH2:18][C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[CH2:12][C:11]=2[CH:32]=1)C.[OH-].[Na+:35]>C(O)C>[CH2:18]([N:17]([C:25]([O:27][C:28]([CH3:31])([CH3:30])[CH3:29])=[O:26])[CH:13]1[CH2:12][C:11]2[CH:32]=[C:7]([O:6][CH2:5][C:4]([O-:33])=[O:3])[CH:8]=[CH:9][C:10]=2[CH2:16][CH2:15][CH2:14]1)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1.[Na+:35]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 54132576HCID 54132576, compound

Product 1

HCID 86585781HCID 86585781, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of [8-(N-benzyl-tert-butoxycarbonylamino)-6,7,8,9-tetrahydro-5H-benzocyclohepten-2-yloxy]acetic acid ethyl ester (2.5 g) in ethanol (25 ml) was added 1N sodium hydroxide aqueous solution at 5° C., and the solution was stirred at room temperature for 1 hour. The resulting solution was evaporated in vacuo to afford sodium [8-(N-benzyl-tert-butoxycarbonylamino)-6,7,8,9-tetrahydro-5H-benzocyclohepten-2-yloxy]acetate (2.35 g).

Workup

  1. customThe resulting solution was evaporated in vacuo

Sources & evidence

ORD record
ord-6a3b68473a774c0fa16fd8e14d8a3a3e
Source dataset
uspto-grants-2007_05
Patent number
US07217706B2

Reaction notes

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