Ammonium Hydroxide → 2-(8-benzylamino-6,7,8,9-tetrahydro-5H-benzocyclohepten-2-yloxy)acetamide

HRID 1351838Notes

Reaction equation

HRID 1351838 reaction equation
C([O:3][C:4](=O)[CH2:5][O:6][C:7]1[CH:8]=[CH:9][C:10]2[CH2:16][CH2:15][CH2:14][CH:13]([NH:17][CH2:18][C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[CH2:12][C:11]=2[CH:25]=1)C.[OH-].[NH4+:28]>CO>[CH2:18]([NH:17][CH:13]1[CH2:12][C:11]2[CH:25]=[C:7]([O:6][CH2:5][C:4]([NH2:28])=[O:3])[CH:8]=[CH:9][C:10]=2[CH2:16][CH2:15][CH2:14]1)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

Participants

4

Reactant 2

HCID 14923Ammonium HydroxideHCID 18007287N-benzyl-3-ethoxycarbonylmethoxy-6,7,8,9-tetrahydro-5H-benzocyclohepten-6-amine

Product 1

HCID 180072092-(8-benzylamino-6,7,8,9-tetrahydro-5H-benzocyclohepten-2-yloxy)acetamide

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 2-(8-benzylamino-6,7,8,9-tetrahydro-5H-benzocyclohepten-2-yloxy)acetic acid ethyl ester (320 mg) and 28% ammonium hydroxide (1 ml) in methanol (3 ml) was stirred at room temperature for 12 hours. The mixture was evaporated in vacuo to give 2-(8-benzylamino-6,7,8,9-tetrahydro-5H-benzocyclohepten-2-yloxy)acetamide (270 mg).

Workup

  1. customThe mixture was evaporated in vacuo

Sources & evidence

ORD record
ord-821a1eda541d4d37ae59d92095ba2e8b
Source dataset
uspto-grants-2007_05
Patent number
US07217706B2

Reaction notes

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