Ammonium Hydroxide → (2S)-(-)-1-Amino-3-phenoxy-2-propanol

HRID 1351844Notes

Reaction equation

HRID 1351844 reaction equation
[O:1]([CH2:8][C@H:9]1[O:11][CH2:10]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[NH4+:13]>C(O)C>[NH2:13][CH2:10][C@H:9]([OH:11])[CH2:8][O:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 14923Ammonium HydroxideHCID 1534345(2S)-2-(phenoxymethyl)oxirane

Product 1

HCID 1133101(2S)-(-)-1-Amino-3-phenoxy-2-propanol

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A stirred solution of (2S)-1-phenoxy-2,3-epoxypropane (1.0 g) and concentrated ammonium hydroxide (10 ml) in ethanol (10 ml) was sealed up at room temperature for 12 hours. The mixture was evaporated in vacuo and dried to give (2S)-1-amino-3-phenoxy-2-propanol (1.1 g).

Workup

  1. customThe mixture was evaporated in vacuo
  2. customdried

Sources & evidence

ORD record
ord-f0ed5dca161d4786a3a69f9130b8baf1
Source dataset
uspto-grants-2007_05
Patent number
US07217706B2

Reaction notes

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