Hydrochloric Acid → HCID 18340060, compound

HRID 1351901Notes

Reaction equation

HRID 1351901 reaction equation
[ClH:1].[OH:2][C@H:3]([CH2:22][O:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)[CH2:4][NH:5][CH:6]1[CH2:12][C:11]2[CH:13]=[C:14]([CH2:17][NH:18]C(=O)C)[CH:15]=[CH:16][C:10]=2[CH2:9][CH2:8][CH2:7]1.Cl>>[ClH:1].[ClH:1].[NH2:18][CH2:17][C:14]1[CH:15]=[CH:16][C:10]2[CH2:9][CH2:8][CH2:7][CH:6]([NH:5][CH2:4][C@H:3]([OH:2])[CH2:22][O:23][C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[CH2:12][C:11]=2[CH:13]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 18340079HCID 18340079, compound

Product 1

HCID 18340060HCID 18340060, compoundYield 190.5%

Procedure

A mixture of N-[8-[(2S)-2-hydroxy-3-phenoxypropyl]amino-6,7,8,9-tetrahydro-5H-benzocyclohepten-2-yl]methyl acetamide hydrochloride (100 mg) and 1N aqueous hydrochloric acid solution (2 ml) was heated to reflux for 18 hours. The solvent was removed under reduced pressure to dryness. The residue was triturated in diisopropyl ether, and the precipitated powder was collected by filtration to afford (2S)-1-[(3-aminomethyl-6,7,8,9-tetrahydro-5H-benzocyclo-hepten-6-yl)amino]-3-phenoxy-2-propanol dihydrochloride (94 mg).

Workup

  1. temperaturewas heated
  2. temperatureto reflux for 18 hours
  3. customThe solvent was removed under reduced pressure to dryness
  4. customThe residue was triturated in diisopropyl ether
  5. filtrationthe precipitated powder was collected by filtration

Sources & evidence

ORD record
ord-440c298f16e0491ab491854370a4c5dc
Source dataset
uspto-grants-2007_05
Patent number
US07217706B2

Reaction notes

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