Lithium diisopropylamide → HCID 58654531, compound

HRID 1351913Notes

Reaction equation

HRID 1351913 reaction equation
[P:1]([CH2:14][CH2:15][CH2:16][P:17]([CH2:24][CH2:25][CH2:26]Cl)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:28]1([PH:34][CH:35]2[CH2:40][CH2:39][CH2:38][CH2:37][CH2:36]2)[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1.C([N-]C(C)C)(C)C.[Li+]>>[P:1]([CH2:14][CH2:15][CH2:16][P:17]([CH2:24][CH2:25][CH2:26][P:34]([CH:35]1[CH2:40][CH2:39][CH2:38][CH2:37][CH2:36]1)[C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 2724682Lithium diisopropylamideHCID 16689846HCID 16689846, compoundHCID 58654533HCID 58654533, compound

Product 1

HCID 58654531HCID 58654531, compound

Procedure

The procedure for the Synthesis of HexPh4P3Pr above was followed using (C6H5)2P(CH2)3P(C6H5)(CH2)3Cl (1.73 g, 4.15 mmol), Phenylcyclohexylphosphine (1.01 g, 6.81 mmol) and lithium diisopropylamide (4.4 ml, 8.8 mmol). Yield: 1.89 g (81.4%). 31P{1H} NMR (CDCl3, 122 MHz, δppm: —CH2P(Cyhex)Ph: −11.67 and −11.79; Ph2PCH2—: −16.52; —CH2P(Ph)CH2— −26.21 and 26.34 (>98% pure).

Workup

  1. customThe procedure for the Synthesis of HexPh4P3Pr

Sources & evidence

ORD record
ord-9a4da0d12b274e1e8e26f0f76a87c155
Source dataset
uspto-grants-2007_05
Patent number
US07217848B2

Reaction notes

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