反应详情

To a solution of (R)-2-chloro-1-pyridin-3-ylethanol (2.0 g, 12.7 mmol) in acetonitrile (100 ml) is added potassium carbonate (7.02 g). The mixture is refluxed for 2.5 hours, and cooled to room temperature. The mixture is filtered, and the filtrate is distilled off under reduced pressure. The resultant is purified by silica gel column chromatography (methanol/chloroform=1/100) to give the title compound (R)-(pyridin-3-yl)oxirane (1.46 g, yield: 94%) as pale yellow oil.

1. temperatureThe mixture is refluxed for 2.5 hours
2. filtrationThe mixture is filtered
3. distillationthe filtrate is distilled off under reduced pressure
4. customThe resultant is purified by silica gel column chromatography (methanol/chloroform=1/100)