反应详情

To a solution of 7-hydroxyindole (2.65 g, 20 mmol) in acetone (20 ml) are added potassium carbonate (3.32 g), chloroacetic acid diethylamide (3.29 g, 22 mmol) and potassium iodide (0.33 g), and the mixture is refluxed for 4 hours. After cooling with ice, the insoluble materials are removed by filtration, and the filtrate is concentrated under reduced pressure to remove the solvent. To the residue are added chloroform (40 ml) and water (20 ml), and the mixture is stirred. The chloroform layer is separated, and dried over anhydrous magnesium sulfate. The solvent is evaporated under reduced pressure, and isopropyl ether (100 ml) is added to the residue. The precipitated crystals are collected by filtration, and dried to give the title compound N,N-diethyl-2-(1H-indol-7-yloxy)acetamide (4.37 g, yield: 89%) as white crystals.

1. temperaturethe mixture is refluxed for 4 hours
2. temperatureAfter cooling with ice
3. customthe insoluble materials are removed by filtration
4. concentrationthe filtrate is concentrated under reduced pressure
5. customto remove the solvent
6. additionTo the residue are added chloroform (40 ml) and water (20 ml)
7. customThe chloroform layer is separated
8. dry with materialdried over anhydrous magnesium sulfate
9. customThe solvent is evaporated under reduced pressure, and isopropyl ether (100 ml)
10. additionis added to the residue
11. filtrationThe precipitated crystals are collected by filtration
12. customdried