Hydrochloric Acid → HCID 69458599, compound

HRID 1351962Notes

Reaction equation

HRID 1351962 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C@H:8]2[O:12][C:11](=[O:13])[N:10]([C@H:14]([CH3:30])[CH2:15][C:16]3[C:24]4[C:19](=[C:20]([C:25]([O:27]CC)=[O:26])[CH:21]=[CH:22][CH:23]=4)[NH:18][CH:17]=3)[CH2:9]2)[CH:5]=[CH:6][CH:7]=1.[OH-].[K+].Cl>O.C(O)C>[Cl:1][C:2]1[CH:3]=[C:4]([C@H:8]2[O:12][C:11](=[O:13])[N:10]([C@H:14]([CH3:30])[CH2:15][C:16]3[C:24]4[C:19](=[C:20]([C:25]([OH:27])=[O:26])[CH:21]=[CH:22][CH:23]=4)[NH:18][CH:17]=3)[CH2:9]2)[CH:5]=[CH:6][CH:7]=1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 69455774HCID 69455774, compound

Product 1

HCID 69458599HCID 69458599, compoundYield 86%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

A solution of ethyl 3-{(2R)-2-[(5R)-5-(3-chlorophenyl)-2-oxo-1,3-oxazolidin-3-yl]propyl}-1H-indole-7-carboxylate (55 mg, 0.129 mmol) and potassium hydroxide (70 mg, 1.3 mmol) in water (1 mL) and ethanol (2 mL) is stirred at room temperature for 3 days. The reaction mixture is neutralized with 1N hydrochloric acid, and the precipitated crystals are collected by filtration to give the title compound (44 mg, yield: 86%).

Workup

  1. filtrationthe precipitated crystals are collected by filtration

Sources & evidence

ORD record
ord-2b81c0a7cc204b8589e23e28bd5351fe
Source dataset
uspto-grants-2007_05
Patent number
US07217724B2

Reaction notes

Loading…