Sodium Hydroxide → HCID 178488589, compound

HRID 1351994Notes

Reaction equation

HRID 1351994 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:11]=1[NH:10][N:9]=[C:8]2[CH2:12][CH2:13][C:14]([O:16]C)=[O:15].[OH-].[Na+]>O1CCCC1>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:11]=1[NH:10][N:9]=[C:8]2[CH2:12][CH2:13][C:14]([OH:16])=[O:15]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 178500077HCID 178500077, compound

Product 1

HCID 178488589HCID 178488589, compoundYield 94%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of methyl 3-(7-methoxy-1H-indazol-3-yl)-propanoate (140 mg, 0.596 mmol) in tetrahydrofuran (2 mL) is added a 6N aqueous sodium hydroxide solution (2 ml), and the mixture is stirred at room temperature overnight. The reaction solution is washed with diethyl ether, and the aqueous layer is acidified with 6N hydrochloric acid, and the mixture is extracted with diethyl ether. The organic layer is dried over anhydrous magnesium sulfate, and the solvent is evaporated under reduced pressure to give the title compound (123 mg, yield: 94%).

Workup

  1. washThe reaction solution is washed with diethyl ether
  2. extractionthe mixture is extracted with diethyl ether
  3. dry with materialThe organic layer is dried over anhydrous magnesium sulfate
  4. customthe solvent is evaporated under reduced pressure

Sources & evidence

ORD record
ord-0e4b11ce30f34f3face162fd4535b119
Source dataset
uspto-grants-2007_05
Patent number
US07217724B2

Reaction notes

Loading…