4-Aminopyridine → HCID 17838265, compound

HRID 1352114Notes

Reaction equation

HRID 1352114 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][N:5]=[CH:4][CH:3]=1.[F:8][C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([F:15])[C:10]=1[N:16]=[C:17]=[O:18]>C1(C)C=CC=CC=1>[F:8][C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([F:15])[C:10]=1[NH:16][C:17]([NH:1][C:2]1[CH:7]=[CH:6][N:5]=[CH:4][CH:3]=1)=[O:18]

Participants

4

Reactant 2

HCID 17274-AminopyridineHCID 5221622,6-Difluorophenyl isocyanate

Product 1

HCID 17838265HCID 17838265, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Conditions

Temperature
110 °C

Procedure

4-Aminopyridine (100 mg, 1.06 mmol) and 2,6-difluorophenyl isocyanate (181.3 mg, 1.17 mmol) were dissolved in toluene, and the mixture was then stirred at 110° C. for 4 hr.

Sources & evidence

ORD record
ord-dd55d3e7b4aa4933a7c0e547be63511f
Source dataset
uspto-grants-2007_05
Patent number
US07217722B2

Reaction notes

Loading…