HCID 21098484, compound → HCID 21098454, compound

HRID 1352125Notes

Reaction equation

HRID 1352125 reaction equation
C([O:8][C:9]1[CH:31]=[CH:30][C:12]([CH2:13][N:14]2[CH2:19][CH2:18][CH:17]([NH:20][C:21]3[CH:22]=[C:23]4[C:27](=[CH:28][CH:29]=3)[NH:26][N:25]=[CH:24]4)[CH2:16][CH2:15]2)=[CH:11][CH:10]=1)C1C=CC=CC=1>C(O)C.[Pd]>[NH:26]1[C:27]2[C:23](=[CH:22][C:21]([NH:20][CH:17]3[CH2:18][CH2:19][N:14]([CH2:13][C:12]4[CH:11]=[CH:10][C:9]([OH:8])=[CH:31][CH:30]=4)[CH2:15][CH2:16]3)=[CH:29][CH:28]=2)[CH:24]=[N:25]1

Participants

4

Reactant 1

HCID 21098484HCID 21098484, compound

Product 1

HCID 21098454HCID 21098454, compoundYield 82%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

N-{1-[4-(Benzyloxy)benzyl]-4-piperidyl}-N-(1H-5-indazolyl)amine (Example 142, 33 mg) and palladium-charcoal (10 mg) were suspended in ethanol (3 ml), and the suspension was stirred under a hydrogen atmosphere of 1 atm at room temperature for 18 hr. The reaction mixture was filtered through Celite, and the filtrate was then concentrated to give the title compound (21 mg, yield 82%).

Workup

  1. filtrationThe reaction mixture was filtered through Celite
  2. concentrationthe filtrate was then concentrated

Sources & evidence

ORD record
ord-a9e3a9161b23437bb8a424970e87c7ed
Source dataset
uspto-grants-2007_05
Patent number
US07217722B2

Reaction notes

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