HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperazine → 2-Piperazin-1-yl-thiazole-5-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperazine | HCID 4837 | — |
| Reactant | 2-Chlorothiazole-5-carbonitrile | HCID 1485222 | — |
| Product | 2-Piperazin-1-yl-thiazole-5-carbonitrile | HCID 21100257 | 86% |
Reaction Steps
Prepared in analogy to example 2 (b) from 2-chloro-1,3-thiazole-5-carbonitrile and piperazine. The crude material was purified by chromatography (SiO2, methanol/dichloromethane) to yield the title compound as a white crystalline solid (yield 86%). MS (m/e): 194.9 (M+H+, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07220744B2 |
| Source dataset | uspto-grants-2007_05 |
| ORD ID | ord-fce90215517c4860b1f7ec6872b1e808 |
| Source note | uspto-grants-2007_05 |