Piperazine → 2-Piperazin-1-yl-thiazole-5-carbonitrile

HRID 1352286Notes

Reaction equation

HRID 1352286 reaction equation
Cl[C:2]1[S:3][C:4]([C:7]#[N:8])=[CH:5][N:6]=1.[NH:9]1[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]1>>[N:9]1([C:2]2[S:3][C:4]([C:7]#[N:8])=[CH:5][N:6]=2)[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]1

Participants

3

Reactant 2

HCID 4837PiperazineHCID 14852222-Chlorothiazole-5-carbonitrile

Product 1

HCID 211002572-Piperazin-1-yl-thiazole-5-carbonitrileYield 86%

Procedure

Prepared in analogy to example 2 (b) from 2-chloro-1,3-thiazole-5-carbonitrile and piperazine. The crude material was purified by chromatography (SiO2, methanol/dichloromethane) to yield the title compound as a white crystalline solid (yield 86%). MS (m/e): 194.9 (M+H+, 100%).

Workup

  1. customThe crude material was purified by chromatography (SiO2, methanol/dichloromethane)

Sources & evidence

ORD record
ord-fce90215517c4860b1f7ec6872b1e808
Source dataset
uspto-grants-2007_05
Patent number
US07220744B2

Reaction notes

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