HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-[4-(2,4-Dichloro-phenyl)-thiazol-2-yl]-piperazine dihydrochloride → {4-[4-(2,4-Dichloro-phenyl)-thiazol-2-yl]-piperazin-1-yl}-(2-isopropoxy-5-methanesulfonyl-phenyl)-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-[4-(2,4-Dichloro-phenyl)-thiazol-2-yl]-piperazine dihydrochloride | HCID 21100173 | — |
| Reactant | 2-Isopropoxy-5-methylsulfonylbenzoic acid | HCID 21100237 | — |
| Product | {4-[4-(2,4-Dichloro-phenyl)-thiazol-2-yl]-piperazin-1-yl}-(2-isopropoxy-5-methanesulfonyl-phenyl)-methanone | HCID 21100260 | 17% |
Reaction Steps
Prepared in analogy to example 1 (b) from 2-isopropoxy-5-methanesulfonyl-benzoic acid (Example A1) and 1-[4-(2,4-dichloro-phenyl)-thiazol-2-yl]-piperazine dihydrochloride. The crude material was purified by chromatography (SiO2, methanol/dichloromethane) (yield 17%). MS (m/e): 558.1 ({37Cl}M+H+, 19%), 555.9 ({37Cl35Cl}M+H+, 58%), 554.1 ({35Cl}M+H+, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07220744B2 |
| Source dataset | uspto-grants-2007_05 |
| ORD ID | ord-1cdb12ce144f4bfca1eb44d35d762bb0 |
| Source note | uspto-grants-2007_05 |