HCID 21100219, compound → HCID 21100208, compound

HRID 1352298Notes

Reaction equation

HRID 1352298 reaction equation
[CH:1]1([O:5][C:6]2[CH:14]=[CH:13][C:12]([S:15]([CH3:18])(=[O:17])=[O:16])=[CH:11][C:7]=2[C:8]([OH:10])=O)[CH2:4][CH2:3][CH2:2]1.[N:19]1([C:25]2[S:26][C:27]([C:30]#[N:31])=[CH:28][N:29]=2)[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1>>[CH:1]1([O:5][C:6]2[CH:14]=[CH:13][C:12]([S:15]([CH3:18])(=[O:17])=[O:16])=[CH:11][C:7]=2[C:8]([N:22]2[CH2:23][CH2:24][N:19]([C:25]3[S:26][C:27]([C:30]#[N:31])=[CH:28][N:29]=3)[CH2:20][CH2:21]2)=[O:10])[CH2:2][CH2:3][CH2:4]1

Participants

3

Reactant 2

HCID 21100219HCID 21100219, compoundHCID 211002572-Piperazin-1-yl-thiazole-5-carbonitrile

Product 1

HCID 21100208HCID 21100208, compoundYield 54%

Procedure

Prepared in analogy to example 1 (b) from 2-cyclobutoxy-5-methanesulfonyl-benzoic acid (Example A9) and 2-piperazin-1-yl-thiazole-5-carbonitrile (Example 6(a)). The crude material was purified by chromatography (SiO2, ethyl acetate/heptane) followed by trituration in ether to yield the title compound as an off-white crystalline solid (yield 54%). MS (m/e): 447.2 (M+H+, 100%).

Workup

  1. customThe crude material was purified by chromatography (SiO2, ethyl acetate/heptane)

Sources & evidence

ORD record
ord-1f3a9eac61014b84ac9a1901927d8d4f
Source dataset
uspto-grants-2007_05
Patent number
US07220744B2

Reaction notes

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