HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 21100219, compound → HCID 21100208, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 21100219 | HCID 21100219 | — |
| Reactant | 2-Piperazin-1-yl-thiazole-5-carbonitrile | HCID 21100257 | — |
| Product | HCID 21100208 | HCID 21100208 | 54% |
Reaction Steps
Prepared in analogy to example 1 (b) from 2-cyclobutoxy-5-methanesulfonyl-benzoic acid (Example A9) and 2-piperazin-1-yl-thiazole-5-carbonitrile (Example 6(a)). The crude material was purified by chromatography (SiO2, ethyl acetate/heptane) followed by trituration in ether to yield the title compound as an off-white crystalline solid (yield 54%). MS (m/e): 447.2 (M+H+, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07220744B2 |
| Source dataset | uspto-grants-2007_05 |
| ORD ID | ord-1f3a9eac61014b84ac9a1901927d8d4f |
| Source note | uspto-grants-2007_05 |