2-(2,2-Dimethyl-propoxy)-5-methanesulfonyl-benzoic acid → HCID 11554441, compound

HRID 1352300Notes

Reaction equation

HRID 1352300 reaction equation
[CH3:1][C:2]([CH3:19])([CH3:18])[CH2:3][O:4][C:5]1[CH:13]=[CH:12][C:11]([S:14]([CH3:17])(=[O:16])=[O:15])=[CH:10][C:6]=1[C:7]([OH:9])=O.[N:20]1([C:26]2[S:27][C:28]([C:31]#[N:32])=[CH:29][N:30]=2)[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]1>>[CH3:18][C:2]([CH3:1])([CH3:19])[CH2:3][O:4][C:5]1[CH:13]=[CH:12][C:11]([S:14]([CH3:17])(=[O:16])=[O:15])=[CH:10][C:6]=1[C:7]([N:23]1[CH2:24][CH2:25][N:20]([C:26]2[S:27][C:28]([C:31]#[N:32])=[CH:29][N:30]=2)[CH2:21][CH2:22]1)=[O:9]

Participants

3

Reactant 2

HCID 211002032-(2,2-Dimethyl-propoxy)-5-methanesulfonyl-benzoic acidHCID 211002572-Piperazin-1-yl-thiazole-5-carbonitrile

Product 1

HCID 11554441HCID 11554441, compoundYield 68%

Procedure

Prepared in analogy to example 1 (b) from 2-(2,2-dimethyl-propoxy)-5-methanesulfonyl-benzoic acid (Example A11) and 2-piperazin-1-yl-thiazole-5-carbonitrile (Example 6(a)). The crude material was purified by chromatography (SiO2, ethyl acetate/heptane) followed by trituration in ether to yield the title compound as a white crystalline solid (yield 68%). MS (m/e): 463.3 (M+H+, 100%).

Workup

  1. customThe crude material was purified by chromatography (SiO2, ethyl acetate/heptane)

Sources & evidence

ORD record
ord-795f983e6c114085b67446db45d17237
Source dataset
uspto-grants-2007_05
Patent number
US07220744B2

Reaction notes

Loading…