2-(2,2-Dimethyl-propoxy)-5-methanesulfonyl-benzoic acid → 2-{4-[2-(2,2-Dimethyl-propoxy)-5-methanesulfonyl-benzoyl]-piperazin-1-yl}-thiazole-5-carbonitrile

Participants

Reaction Steps

Prepared in analogy to example 1 (b) from 2-(2,2-dimethyl-propoxy)-5-methanesulfonyl-benzoic acid (Example A11) and 2-piperazin-1-yl-thiazole-5-carbonitrile (Example 6(a)). The crude material was purified by chromatography (SiO2, ethyl acetate/heptane) followed by trituration in ether to yield the title compound as a white crystalline solid (yield 68%). MS (m/e): 463.3 (M+H+, 100%).

Provenance & Evidence