Hydrochloric Acid → HCID 21100187, compound

HRID 1352303Notes

Reaction equation

C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[S:15][C:16]([S:19]([CH3:22])(=[O:21])=[O:20])=[CH:17][N:18]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:23]>>[ClH:23].[CH3:22][S:19]([C:16]1[S:15][C:14]([N:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)=[N:18][CH:17]=1)(=[O:20])=[O:21]

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 67549709HCID 67549709, compound

Product 1

HCID 21100187HCID 21100187, compoundYield 99%

Procedure

Prepared in analogy to example 4 (d) from 4-(5-methanesulfonyl-thiazol-2-yl)-piperazine-1-carboxylic acid tert-butyl ester and hydrogen chloride solution. The crude material was purified by recrystallisation from ether to afford the title compound as a light brown crystalline solid (yield 99%). MS (m/e): 248.1 (M+H+, 100%).

Workup

customThe crude material was purified by recrystallisation from ether

Sources & evidence

ORD record: ord-cf837a18d41d4329bb62fe52d623bb8e
Source dataset: uspto-grants-2007_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07220744B2

Reaction notes

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