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HRID1352308

反应详情

EQUATION

反应方程式

HRID 1352308 的结构方程式

REACTANTS

反应物

2
结构：CS(=O)(=O)c1cnc(N2CCNCC2)s1.Cl
HCID21100187

未命名化合物

结构：CCC(C)Oc1ccc(S(C)(=O)=O)cc1C(=O)O
HCID21100258

未命名化合物

PRODUCTS

生成物

1
结构：CCC(C)Oc1ccc(S(C)(=O)=O)cc1C(=O)N1CCN(c2ncc(S(C)(=O)=O)s2)CC1
HCID21100323

未命名化合物

收率 44%

PROCEDURE

实验过程

Prepared in analogy to example 1 (b) from rac-2-sec-butoxy-5-methanesulfonyl-benzoic acid (Example A10) and 1-(5-methanesulfonyl-thiazol-2-yl)-piperazine hydrochloride (Example 21(c)). The crude material was purified by chromatography (SiO2, ethyl acetate/heptane) followed by trituration in ether to yield the title compound as an off-white crystalline solid (yield 44%). MS (m/e): 502.1 (M+H+, 99%), 519.3 (M+NH4+, 100%).

WORKUP

后处理

  1. customThe crude material was purified by chromatography (SiO2, ethyl acetate/heptane)