HCID 21100187, compound → Rac-(2-sec-butoxy-5-methanesulfonyl-phenyl)-[4-(5-methanesulfonyl-thiazol-2-yl)-piperazin-1-yl]-methanone

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Reaction Steps

Prepared in analogy to example 1 (b) from rac-2-sec-butoxy-5-methanesulfonyl-benzoic acid (Example A10) and 1-(5-methanesulfonyl-thiazol-2-yl)-piperazine hydrochloride (Example 21(c)). The crude material was purified by chromatography (SiO2, ethyl acetate/heptane) followed by trituration in ether to yield the title compound as an off-white crystalline solid (yield 44%). MS (m/e): 502.1 (M+H+, 99%), 519.3 (M+NH4+, 100%).

Provenance & Evidence