HCID 21100187, compound → HCID 21100222, compound

HRID 1352310Notes

Reaction equation

HRID 1352310 reaction equation
[CH:1]1([O:7][C:8]2[CH:16]=[CH:15][C:14]([S:17]([CH3:20])(=[O:19])=[O:18])=[CH:13][C:9]=2[C:10]([OH:12])=O)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.Cl.[CH3:22][S:23]([C:26]1[S:30][C:29]([N:31]2[CH2:36][CH2:35][NH:34][CH2:33][CH2:32]2)=[N:28][CH:27]=1)(=[O:25])=[O:24]>>[CH:1]1([O:7][C:8]2[CH:16]=[CH:15][C:14]([S:17]([CH3:20])(=[O:19])=[O:18])=[CH:13][C:9]=2[C:10]([N:34]2[CH2:35][CH2:36][N:31]([C:29]3[S:30][C:26]([S:23]([CH3:22])(=[O:25])=[O:24])=[CH:27][N:28]=3)[CH2:32][CH2:33]2)=[O:12])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

3

Reactant 2

HCID 21100187HCID 21100187, compoundHCID 211002212-Cyclohexyloxy-5-methanesulfonyl-benzoic acid

Product 1

HCID 21100222HCID 21100222, compoundYield 38%

Procedure

Prepared in analogy to example 1 (b) from 2-cyclohexyloxy-5-methanesulfonyl-benzoic acid (Example A7) and 1-(5-methanesulfonyl-thiazol-2-yl)-piperazine hydrochloride (Example 21(c)). The crude material was purified by chromatography (SiO2, ethyl acetate/heptane) followed by trituration in ether to yield the title compound as a light red crystalline solid (yield 38%). MS (m/e): 528.3 (M+H+, 100%).

Workup

  1. customThe crude material was purified by chromatography (SiO2, ethyl acetate/heptane)

Sources & evidence

ORD record
ord-0a92c716510542ddabee5b02547ea288
Source dataset
uspto-grants-2007_05
Patent number
US07220744B2

Reaction notes

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