HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 21100187, compound → HCID 21100222, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 21100187 | HCID 21100187 | — |
| Reactant | 2-Cyclohexyloxy-5-methanesulfonyl-benzoic acid | HCID 21100221 | — |
| Product | HCID 21100222 | HCID 21100222 | 38% |
Reaction Steps
Prepared in analogy to example 1 (b) from 2-cyclohexyloxy-5-methanesulfonyl-benzoic acid (Example A7) and 1-(5-methanesulfonyl-thiazol-2-yl)-piperazine hydrochloride (Example 21(c)). The crude material was purified by chromatography (SiO2, ethyl acetate/heptane) followed by trituration in ether to yield the title compound as a light red crystalline solid (yield 38%). MS (m/e): 528.3 (M+H+, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07220744B2 |
| Source dataset | uspto-grants-2007_05 |
| ORD ID | ord-0a92c716510542ddabee5b02547ea288 |
| Source note | uspto-grants-2007_05 |