化工社化工社 化学情報印刷レポート · 研究参考用
Diethyl disulfide → 4-(5-Ethylsulfanyl-thiazol-2-yl)-piperazine-1-carboxylic acid tert-butyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diethyl disulfide | HCID 8077 | — |
| 反応物 | Tert-butyl 4-(5-bromo-1,3-thiazol-2-yl)piperazine-1-carboxylate | HCID 34180719 | — |
| 生成物 | 4-(5-Ethylsulfanyl-thiazol-2-yl)-piperazine-1-carboxylic acid tert-butyl ester | HCID 68406776 | 86% |
反応手順
Prepared in analogy to example 4 (b) from 4-(5-bromo-thiazol-2-yl)-piperazine-1-carboxylic acid tert-butyl ester (Example 4(a)) and diethyl disulphide. The crude material was purified by chromatography (SiO2, ethyl acetate/heptane) to afford the title compound as a white crystalline solid (yield 86%). MS (m/e): 330.3 (M+H+, 100%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07220744B2 |
| 出典データセット | uspto-grants-2007_05 |
| ORD ID | ord-df82ae43cd314053849c8ae2fa57d49b |
| 出典メモ | uspto-grants-2007_05 |