1-(5-Ethanesulfonyl-thiazol-2-yl)-piperazine hydrochloride → [2-(2,2-Dimethyl-propoxy)-5-methanesulfonyl-phenyl]-[4-(5-ethanesulfonyl-thiazol-2-yl)-piperazin-1-yl]-methanone

Participants

Reaction Steps

Prepared in analogy to example 1 (b) from 2-(2,2-dimethyl-propoxy)-5-methanesulfonyl-benzoic acid (Example A11) and 1-(5-ethanesulfonyl-thiazol-2-yl)-piperazine hydrochloride. The crude material was purified by chromatography (SiO2, ethyl acetate/heptane) followed by trituration in ether to yield the title compound as a white crystalline solid (yield 63%). MS (m/e): 530.2 (M+H+, 64%), 547.2 (M+NH4+, 100%).

Provenance & Evidence