1-(4,5-Dimethyl-1,3-thiazol-2-yl)piperazine → HCID 21100261, compound

HRID 1352320Notes

Reaction equation

HRID 1352320 reaction equation
[CH:1]([O:4][C:5]1[CH:13]=[CH:12][C:11]([S:14]([CH3:17])(=[O:16])=[O:15])=[CH:10][C:6]=1[C:7]([OH:9])=O)([CH3:3])[CH3:2].[CH3:18][C:19]1[N:20]=[C:21]([N:25]2[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]2)[S:22][C:23]=1[CH3:24]>>[CH3:18][C:19]1[N:20]=[C:21]([N:25]2[CH2:26][CH2:27][N:28]([C:7]([C:6]3[CH:10]=[C:11]([S:14]([CH3:17])(=[O:16])=[O:15])[CH:12]=[CH:13][C:5]=3[O:4][CH:1]([CH3:2])[CH3:3])=[O:9])[CH2:29][CH2:30]2)[S:22][C:23]=1[CH3:24]

Participants

3

Reactant 2

HCID 199157651-(4,5-Dimethyl-1,3-thiazol-2-yl)piperazineHCID 211002372-Isopropoxy-5-methylsulfonylbenzoic acid

Product 1

HCID 21100261HCID 21100261, compoundYield 65%

Procedure

Prepared in analogy to example 1 (b) from 2-isopropoxy-5-methanesulfonyl-benzoic acid (Example A1) and 1-(4,5-dimethyl-thiazol-2-yl)-piperazine. The crude material was purified by chromatography (SiO2, ethyl acetate/heptane) followed by trituration in ether to yield the title compound as an off-white crystalline solid (yield 65%). MS (m/e): 584.3 (M+H+, 100%), 601.4 (M+NH4+, 60%).

Workup

  1. customThe crude material was purified by chromatography (SiO2, ethyl acetate/heptane)

Sources & evidence

ORD record
ord-7db20309a9a640b083c91f564ee669ef
Source dataset
uspto-grants-2007_05
Patent number
US07220744B2

Reaction notes

Loading…