Hydrochloric Acid → HCID 21100183, compound

HRID 1352324Notes

Reaction equation

HRID 1352324 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[S:15][C:16]([S:19]([CH2:22][CH2:23][CH2:24][CH3:25])(=[O:21])=[O:20])=[CH:17][N:18]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:26]>>[ClH:26].[CH2:22]([S:19]([C:16]1[S:15][C:14]([N:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)=[N:18][CH:17]=1)(=[O:21])=[O:20])[CH2:23][CH2:24][CH3:25]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 684062754-[5-(Butane-1-sulfonyl)-thiazol-2-yl]-piperazine-1-carboxylic acid tert-butyl ester

Product 1

HCID 21100183HCID 21100183, compoundYield 92%

Procedure

Prepared in analogy to example 4 (d) from 4-[5-(butane-1-sulfonyl)-thiazol-2-yl]-piperazine-1-carboxylic acid tert-butyl ester and hydrogen chloride solution. The crude material was purified by recrystallisation from ether to afford the title compound as an off-white crystalline solid (yield 92%). MS (m/e): 290.0 (M+H+, 100%).

Workup

  1. customThe crude material was purified by recrystallisation from ether

Sources & evidence

ORD record
ord-2474e024cdd74c16a883b8b4b475bbf1
Source dataset
uspto-grants-2007_05
Patent number
US07220744B2

Reaction notes

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