Hydrochloric Acid → HCID 21100193, compound

HRID 1352334Notes

Reaction equation

C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[S:15][C:16]([S:19]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][N:23]=3)(=[O:21])=[O:20])=[CH:17][N:18]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:28]>>[ClH:28].[N:23]1[CH:24]=[CH:25][CH:26]=[CH:27][C:22]=1[S:19]([C:16]1[S:15][C:14]([N:11]2[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]2)=[N:18][CH:17]=1)(=[O:20])=[O:21]

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 68408150HCID 68408150, compound

Product 1

HCID 21100193HCID 21100193, compoundYield 99%

Procedure

Prepared in analogy to example 4 (d) from 4-[5-(pyridine-2-sulfonyl)-thiazol-2-yl]-piperazine-1-carboxylic acid tert-butyl ester and hydrogen chloride solution. The crude material was purified by recrystallisation from ether to afford the title compound as an off-white crystalline solid (yield 99%). MS (m/e): 311.0 (M+H+, 100%).

Workup

customThe crude material was purified by recrystallisation from ether

Sources & evidence

ORD record: ord-c20b5581b3444f298f85d1910234cc88
Source dataset: uspto-grants-2007_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07220744B2

Reaction notes

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