HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 1-[5-(Pyridine-3-sulfonyl)-thiazol-2-yl]-piperazine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 4-[5-(Pyridine-3-sulfonyl)-thiazol-2-yl]-piperazine-1-carboxylic acid tert-butyl ester | HCID 67549691 | — |
| Product | 1-[5-(Pyridine-3-sulfonyl)-thiazol-2-yl]-piperazine hydrochloride | HCID 21100195 | 99% |
Reaction Steps
Prepared in analogy to example 4 (d) from 4-[5-(pyridine-3-sulfonyl)-thiazol-2-yl]-piperazine-1-carboxylic acid tert-butyl ester and hydrogen chloride solution. The crude material was purified by recrystallisation from ether to afford the title compound as an off-white crystalline solid (yield 99%). MS (m/e): 311.0 (M+H+, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07220744B2 |
| Source dataset | uspto-grants-2007_05 |
| ORD ID | ord-ae4c10c3f14a4780b573c6aacf0ff731 |
| Source note | uspto-grants-2007_05 |