Hydrochloric Acid → 1-[5-(Pyridine-3-sulfonyl)-thiazol-2-yl]-piperazine hydrochloride

HRID 1352336Notes

Reaction equation

HRID 1352336 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[S:15][C:16]([S:19]([C:22]3[CH:23]=[N:24][CH:25]=[CH:26][CH:27]=3)(=[O:21])=[O:20])=[CH:17][N:18]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:28]>>[ClH:28].[N:24]1[CH:25]=[CH:26][CH:27]=[C:22]([S:19]([C:16]2[S:15][C:14]([N:11]3[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]3)=[N:18][CH:17]=2)(=[O:20])=[O:21])[CH:23]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 675496914-[5-(Pyridine-3-sulfonyl)-thiazol-2-yl]-piperazine-1-carboxylic acid tert-butyl ester

Product 1

HCID 211001951-[5-(Pyridine-3-sulfonyl)-thiazol-2-yl]-piperazine hydrochlorideYield 99%

Procedure

Prepared in analogy to example 4 (d) from 4-[5-(pyridine-3-sulfonyl)-thiazol-2-yl]-piperazine-1-carboxylic acid tert-butyl ester and hydrogen chloride solution. The crude material was purified by recrystallisation from ether to afford the title compound as an off-white crystalline solid (yield 99%). MS (m/e): 311.0 (M+H+, 100%).

Workup

  1. customThe crude material was purified by recrystallisation from ether

Sources & evidence

ORD record
ord-ae4c10c3f14a4780b573c6aacf0ff731
Source dataset
uspto-grants-2007_05
Patent number
US07220744B2

Reaction notes

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