1-[5-(Pyridine-3-sulfonyl)-thiazol-2-yl]-piperazine hydrochloride → (2-Isopropoxy-5-methanesulfonyl-phenyl)-{4-[5-(pyridine-3-sulfonyl)-thiazol-2-yl]-piperazin-1-yl}-methanone

Participants

Reaction Steps

Prepared in analogy to example 1 (b) from 2-isopropoxy-5-methanesulfonyl-benzoic acid (Example A1) and 1-[5-(pyridine-3-sulfonyl)-thiazol-2-yl]-piperazine hydrochloride. The crude material was purified by chromatography (SiO2, ethyl acetate/heptane) followed by trituration in ether to yield the title compound as an off-white crystalline solid (yield 87%). MS (m/e): 551.3 (M+H+, 100%).

Provenance & Evidence