Hydrochloric Acid → HCID 21100197, compound

HRID 1352344Notes

Reaction equation

C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[S:15][C:16]([S:19]([C:22]3[CH:27]=[CH:26][N:25]=[CH:24][CH:23]=3)(=[O:21])=[O:20])=[CH:17][N:18]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:28]>>[ClH:28].[N:25]1[CH:24]=[CH:23][C:22]([S:19]([C:16]2[S:15][C:14]([N:11]3[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]3)=[N:18][CH:17]=2)(=[O:20])=[O:21])=[CH:27][CH:26]=1

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 67548975HCID 67548975, compound

Product 1

HCID 21100197HCID 21100197, compoundYield 99%

Procedure

Prepared in analogy to example 4 (d) from 4-[5-(pyridine-4-sulfonyl)-thiazol-2-yl]-piperazine-1-carboxylic acid tert-butyl ester and hydrogen chloride solution. The crude material was purified by recrystallisation from ether to afford the title compound as a light yellow crystalline solid (yield 99%). MS (m/e): 311.0 (M+H+, 100%).

Workup

customThe crude material was purified by recrystallisation from ether

Sources & evidence

ORD record: ord-bb5be039301f42bea86dd515a225272f
Source dataset: uspto-grants-2007_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07220744B2

Reaction notes

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