1-Piperazinecarbothioamide → 1-[4-(2,2,2-Trifluoro-ethyl)-thiazol-2-yl]-piperazine

HRID 1352350Notes

Reaction equation

[N:1]1([C:7](=[S:9])[NH2:8])[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.Br[CH2:11][C:12](=O)[CH2:13][C:14]([F:17])([F:16])[F:15]>>[F:15][C:14]([F:17])([F:16])[CH2:13][C:12]1[N:8]=[C:7]([N:1]2[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]2)[S:9][CH:11]=1

Participants

Reactant 2

HCID 47396381-Piperazinecarbothioamide

HCID 211002021-Bromo-4,4,4-trifluoro-2-butanone

Product 1

HCID 211001721-[4-(2,2,2-Trifluoro-ethyl)-thiazol-2-yl]-piperazineYield 24%

Procedure

Prepared in analogy to example 49 (a) from 1-piperazinecarbothioamide and 1-bromo-4,4,4-trifluoro-butan-2-one. The crude material was purified by chromatography (SiO2, methanol/dichloromethane) to yield the title compound as a brown oil (yield 24%). MS (m/e): 252.3 (M+H+, 100%).

Workup

customThe crude material was purified by chromatography (SiO2, methanol/dichloromethane)

Sources & evidence

ORD record: ord-eedcf6cd32484b7e84ee966bda90eaca
Source dataset: uspto-grants-2007_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07220744B2

Reaction notes

Loading…