HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Piperazinecarbothioamide → 1-[4-(2,2,2-Trifluoro-ethyl)-thiazol-2-yl]-piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Piperazinecarbothioamide | HCID 4739638 | — |
| Reactant | 1-Bromo-4,4,4-trifluoro-2-butanone | HCID 21100202 | — |
| Product | 1-[4-(2,2,2-Trifluoro-ethyl)-thiazol-2-yl]-piperazine | HCID 21100172 | 24% |
Reaction Steps
Prepared in analogy to example 49 (a) from 1-piperazinecarbothioamide and 1-bromo-4,4,4-trifluoro-butan-2-one. The crude material was purified by chromatography (SiO2, methanol/dichloromethane) to yield the title compound as a brown oil (yield 24%). MS (m/e): 252.3 (M+H+, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07220744B2 |
| Source dataset | uspto-grants-2007_05 |
| ORD ID | ord-eedcf6cd32484b7e84ee966bda90eaca |
| Source note | uspto-grants-2007_05 |