1-(5-Trifluoromethyl-thiazol-2-yl)-piperazine hydrochloride → HCID 11526767, compound

HRID 1352366Notes

Reaction equation

HRID 1352366 reaction equation
[CH3:1][S:2]([C:5]1[CH:6]=[CH:7][C:8]([O:14][C:15]([CH3:21])([CH3:20])[C:16]([F:19])([F:18])[F:17])=[C:9]([CH:13]=1)[C:10]([OH:12])=O)(=[O:4])=[O:3].Cl.[F:23][C:24]([F:37])([F:36])[C:25]1[S:29][C:28]([N:30]2[CH2:35][CH2:34][NH:33][CH2:32][CH2:31]2)=[N:27][CH:26]=1>>[CH3:1][S:2]([C:5]1[CH:6]=[CH:7][C:8]([O:14][C:15]([CH3:21])([CH3:20])[C:16]([F:18])([F:17])[F:19])=[C:9]([C:10]([N:33]2[CH2:34][CH2:35][N:30]([C:28]3[S:29][C:25]([C:24]([F:37])([F:23])[F:36])=[CH:26][N:27]=3)[CH2:31][CH2:32]2)=[O:12])[CH:13]=1)(=[O:3])=[O:4]

Participants

3

Reactant 2

HCID 211002001-(5-Trifluoromethyl-thiazol-2-yl)-piperazine hydrochlorideHCID 211003045-Methanesulfonyl-2-(2,2,2-trifluoro-1,1-dimethyl-ethoxy)-benzoic acid

Product 1

HCID 11526767HCID 11526767, compoundYield 52%

Procedure

Prepared in analogy to example 1 (b) from 5-methanesulfonyl-2-(2,2,2-trifluoro-1,1-dimethyl-ethoxy)-benzoic acid (Example A14) and 1-(5-trifluoromethyl-thiazol-2-yl)-piperazine hydrochloride (Example 58(c)). The crude material was purified by chromatography (ethyl acetate/heptane) to yield the title compound as a white solid (yield 52%). MS (m/e): 546.3 (M+H+, 100%). B.p.=182–183° C.

Workup

  1. customThe crude material was purified by chromatography (ethyl acetate/heptane)

Sources & evidence

ORD record
ord-0bd7f2504f434037b06534105cc26f5d
Source dataset
uspto-grants-2007_05
Patent number
US07220744B2

Reaction notes

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