HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(5-Trifluoromethyl-thiazol-2-yl)-piperazine hydrochloride → HCID 11526767, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(5-Trifluoromethyl-thiazol-2-yl)-piperazine hydrochloride | HCID 21100200 | — |
| Reactant | 5-Methanesulfonyl-2-(2,2,2-trifluoro-1,1-dimethyl-ethoxy)-benzoic acid | HCID 21100304 | — |
| Product | HCID 11526767 | HCID 11526767 | 52% |
Reaction Steps
Prepared in analogy to example 1 (b) from 5-methanesulfonyl-2-(2,2,2-trifluoro-1,1-dimethyl-ethoxy)-benzoic acid (Example A14) and 1-(5-trifluoromethyl-thiazol-2-yl)-piperazine hydrochloride (Example 58(c)). The crude material was purified by chromatography (ethyl acetate/heptane) to yield the title compound as a white solid (yield 52%). MS (m/e): 546.3 (M+H+, 100%). B.p.=182–183° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07220744B2 |
| Source dataset | uspto-grants-2007_05 |
| ORD ID | ord-0bd7f2504f434037b06534105cc26f5d |
| Source note | uspto-grants-2007_05 |