1-[5-(2,2,2-Trifluoro-ethyl)-thiazol-2-yl]-piperazine hydrochloride → HCID 21100242, compound

HRID 1352377Notes

Reaction equation

HRID 1352377 reaction equation
[CH:1]([O:4][C:5]1[CH:13]=[CH:12][C:11]([S:14]([CH3:17])(=[O:16])=[O:15])=[CH:10][C:6]=1[C:7]([OH:9])=O)([CH3:3])[CH3:2].Cl.[F:19][C:20]([F:34])([F:33])[CH2:21][C:22]1[S:26][C:25]([N:27]2[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]2)=[N:24][CH:23]=1>>[CH:1]([O:4][C:5]1[CH:13]=[CH:12][C:11]([S:14]([CH3:17])(=[O:16])=[O:15])=[CH:10][C:6]=1[C:7]([N:30]1[CH2:31][CH2:32][N:27]([C:25]2[S:26][C:22]([CH2:21][C:20]([F:34])([F:19])[F:33])=[CH:23][N:24]=2)[CH2:28][CH2:29]1)=[O:9])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 211001791-[5-(2,2,2-Trifluoro-ethyl)-thiazol-2-yl]-piperazine hydrochlorideHCID 211002372-Isopropoxy-5-methylsulfonylbenzoic acid

Product 1

HCID 21100242HCID 21100242, compoundYield 36%

Procedure

Prepared in analogy to example 1 (b) from 2-isopropoxy-5-methanesulfonyl-benzoic acid (Example A1) and 1-[5-(2,2,2-trifluoro-ethyl)-thiazol-2-yl]-piperazine hydrochloride (Example 69(e)). The crude material was purified by chromatography (SiO2, ethyl acetate/heptane) to yield the title compound as a white crystalline solid (yield 36%). MS (m/e): 492.4 (M+H+, 100%).

Workup

  1. customThe crude material was purified by chromatography (SiO2, ethyl acetate/heptane)

Sources & evidence

ORD record
ord-8c5bfad53a8d44559b58eee5cc3f35d8
Source dataset
uspto-grants-2007_05
Patent number
US07220744B2

Reaction notes

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