HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-[5-(2,2,2-Trifluoro-ethyl)-thiazol-2-yl]-piperazine hydrochloride → HCID 21100242, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-[5-(2,2,2-Trifluoro-ethyl)-thiazol-2-yl]-piperazine hydrochloride | HCID 21100179 | — |
| Reactant | 2-Isopropoxy-5-methylsulfonylbenzoic acid | HCID 21100237 | — |
| Product | HCID 21100242 | HCID 21100242 | 36% |
Reaction Steps
Prepared in analogy to example 1 (b) from 2-isopropoxy-5-methanesulfonyl-benzoic acid (Example A1) and 1-[5-(2,2,2-trifluoro-ethyl)-thiazol-2-yl]-piperazine hydrochloride (Example 69(e)). The crude material was purified by chromatography (SiO2, ethyl acetate/heptane) to yield the title compound as a white crystalline solid (yield 36%). MS (m/e): 492.4 (M+H+, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07220744B2 |
| Source dataset | uspto-grants-2007_05 |
| ORD ID | ord-8c5bfad53a8d44559b58eee5cc3f35d8 |
| Source note | uspto-grants-2007_05 |