1-(2-Piperazin-1-yl-thiazol-5-yl)-propan-1-one hydrochloride → 1-{2-[4-(2-Isopropoxy-5-methanesulfonyl-benzoyl)-piperazin-1-yl]-thiazol-5-yl}-propan-1-one

HRID 1352396Notes

Reaction equation

HRID 1352396 reaction equation
[CH:1]([O:4][C:5]1[CH:13]=[CH:12][C:11]([S:14]([CH3:17])(=[O:16])=[O:15])=[CH:10][C:6]=1[C:7]([OH:9])=O)([CH3:3])[CH3:2].Cl.[N:19]1([C:25]2[S:26][C:27]([C:30](=[O:33])[CH2:31][CH3:32])=[CH:28][N:29]=2)[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1>>[CH:1]([O:4][C:5]1[CH:13]=[CH:12][C:11]([S:14]([CH3:17])(=[O:16])=[O:15])=[CH:10][C:6]=1[C:7]([N:22]1[CH2:23][CH2:24][N:19]([C:25]2[S:26][C:27]([C:30](=[O:33])[CH2:31][CH3:32])=[CH:28][N:29]=2)[CH2:20][CH2:21]1)=[O:9])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 211001701-(2-Piperazin-1-yl-thiazol-5-yl)-propan-1-one hydrochlorideHCID 211002372-Isopropoxy-5-methylsulfonylbenzoic acid

Product 1

HCID 211001691-{2-[4-(2-Isopropoxy-5-methanesulfonyl-benzoyl)-piperazin-1-yl]-thiazol-5-yl}-propan-1-oneYield 24%

Procedure

Prepared in analogy to example 1 (b) from 2-isopropoxy-5-methanesulfonyl-benzoic acid (Example A1) and 1-(2-piperazin-1-yl-thiazol-5-yl)-propan-1-one hydrochloride. The crude material was purified by chromatography (SiO2, methanol/dichloromethane) to yield the title compound as a light brown crystalline solid (yield 24%). MS (m/e): 466.0 (M+H+, 100%).

Workup

  1. customThe crude material was purified by chromatography (SiO2, methanol/dichloromethane)

Sources & evidence

ORD record
ord-560e5cd6efe1401fb49b8585caa76966
Source dataset
uspto-grants-2007_05
Patent number
US07220744B2

Reaction notes

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