HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(2-Piperazin-1-yl-thiazol-5-yl)-propan-1-one hydrochloride → 1-{2-[4-(2-Isopropoxy-5-methanesulfonyl-benzoyl)-piperazin-1-yl]-thiazol-5-yl}-propan-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(2-Piperazin-1-yl-thiazol-5-yl)-propan-1-one hydrochloride | HCID 21100170 | — |
| Reactant | 2-Isopropoxy-5-methylsulfonylbenzoic acid | HCID 21100237 | — |
| Product | 1-{2-[4-(2-Isopropoxy-5-methanesulfonyl-benzoyl)-piperazin-1-yl]-thiazol-5-yl}-propan-1-one | HCID 21100169 | 24% |
Reaction Steps
Prepared in analogy to example 1 (b) from 2-isopropoxy-5-methanesulfonyl-benzoic acid (Example A1) and 1-(2-piperazin-1-yl-thiazol-5-yl)-propan-1-one hydrochloride. The crude material was purified by chromatography (SiO2, methanol/dichloromethane) to yield the title compound as a light brown crystalline solid (yield 24%). MS (m/e): 466.0 (M+H+, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07220744B2 |
| Source dataset | uspto-grants-2007_05 |
| ORD ID | ord-560e5cd6efe1401fb49b8585caa76966 |
| Source note | uspto-grants-2007_05 |