HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bromopinacolone → 4-[5-(2,2-Dimethyl-propionyl)-thiazol-2-yl]-piperazine-1-carboxylic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bromopinacolone | HCID 21642 | — |
| Reactant | 4-(Dimethylaminomethylene-thiocarbamoyl)-piperazine-1-carboxylic acid tert-butyl ester | HCID 86606774 | — |
| Product | 4-[5-(2,2-Dimethyl-propionyl)-thiazol-2-yl]-piperazine-1-carboxylic acid tert-butyl ester | HCID 68406780 | 87% |
Reaction Steps
Prepared in analogy to example 82 (b) from 4-(dimethylaminomethylene-thiocarbamoyl)-piperazine-1-carboxylic acid tert-butyl ester (Example 82(a)) and 1-bromo-pinacolone. The crude material was purified by chromatography (SiO2, ethyl acetate/heptane) to afford the title compound as a white crystalline solid (yield 87%). MS (m/e): 354.3 (M+H+, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07220744B2 |
| Source dataset | uspto-grants-2007_05 |
| ORD ID | ord-1856b7618823424ba2f47d02fc32d556 |
| Source note | uspto-grants-2007_05 |