1-(5-Trifluoromethyl-thiazol-2-yl)-piperazine hydrochloride → HCID 21100232, compound

HRID 1352400Notes

Reaction equation

HRID 1352400 reaction equation
[CH2:1]([S:3][C:4]1[CH:12]=[CH:11][C:10]([S:13]([CH3:16])(=[O:15])=[O:14])=[CH:9][C:5]=1[C:6]([OH:8])=O)[CH3:2].Cl.[F:18][C:19]([F:32])([F:31])[C:20]1[S:24][C:23]([N:25]2[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]2)=[N:22][CH:21]=1>>[CH2:1]([S:3][C:4]1[CH:12]=[CH:11][C:10]([S:13]([CH3:16])(=[O:15])=[O:14])=[CH:9][C:5]=1[C:6]([N:28]1[CH2:29][CH2:30][N:25]([C:23]2[S:24][C:20]([C:19]([F:32])([F:18])[F:31])=[CH:21][N:22]=2)[CH2:26][CH2:27]1)=[O:8])[CH3:2]

Participants

3

Reactant 2

HCID 211002001-(5-Trifluoromethyl-thiazol-2-yl)-piperazine hydrochlorideHCID 21100231HCID 21100231, compound

Product 1

HCID 21100232HCID 21100232, compoundYield 41%

Procedure

Prepared in analogy to example 1 (b) from 2-ethylsulfanyl-5-methanesulfonyl-benzoic acid (Example A23) and 1-(5-trifluoromethyl-thiazol-2-yl)-piperazine hydrochloride (Example 58(c)). The crude material was purified by chromatography (SiO2, ethyl acetate/heptane) to yield the title compound as a white foam (yield 41%). MS (m/e): 479.8 (M+H+, 100%).

Workup

  1. customThe crude material was purified by chromatography (SiO2, ethyl acetate/heptane)

Sources & evidence

ORD record
ord-3c0a193d4d024cc69486bddb84b925c6
Source dataset
uspto-grants-2007_05
Patent number
US07220744B2

Reaction notes

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