HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(5-Trifluoromethyl-thiazol-2-yl)-piperazine hydrochloride → (2-Isobutylsulfanyl-5-methanesulfonyl-phenyl)-[4-(5-trifluoromethyl-thiazol-2-yl)-piperazin-1-yl]-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(5-Trifluoromethyl-thiazol-2-yl)-piperazine hydrochloride | HCID 21100200 | — |
| Reactant | 2-Isobutylsulfanyl-5-methanesulfonyl-benzoic acid | HCID 21100235 | — |
| Product | (2-Isobutylsulfanyl-5-methanesulfonyl-phenyl)-[4-(5-trifluoromethyl-thiazol-2-yl)-piperazin-1-yl]-methanone | HCID 21100236 | 88% |
Reaction Steps
Prepared in analogy to example 1 (b) from 2-isobutylsulfanyl-5-methanesulfonyl-benzoic acid (Example A25) and 1-(5-trifluoromethyl-thiazol-2-yl)-piperazine hydrochloride (Example 58(c)). The crude material was purified by chromatography (SiO2, ethyl acetate/heptane) to yield the title compound as a light yellow solid (yield 88%). MS (m/e): 508.3 (M+H+, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07220744B2 |
| Source dataset | uspto-grants-2007_05 |
| ORD ID | ord-1e23d88c59de453384d7f21bc6464a53 |
| Source note | uspto-grants-2007_05 |