2-Piperazin-1-yl-thiazole-5-carbonitrile → 2-[4-(5-Cyano-2-isopropoxy-benzoyl)-piperazin-1-yl]-thiazole-5-carbonitrile

HRID 1352410Notes

Reaction equation

HRID 1352410 reaction equation
[C:1]([C:3]1[CH:4]=[CH:5][C:6]([O:12][CH:13]([CH3:15])[CH3:14])=[C:7]([CH:11]=1)[C:8]([OH:10])=O)#[N:2].[N:16]1([C:22]2[S:23][C:24]([C:27]#[N:28])=[CH:25][N:26]=2)[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]1>>[C:1]([C:3]1[CH:4]=[CH:5][C:6]([O:12][CH:13]([CH3:15])[CH3:14])=[C:7]([CH:11]=1)[C:8]([N:19]1[CH2:20][CH2:21][N:16]([C:22]2[S:23][C:24]([C:27]#[N:28])=[CH:25][N:26]=2)[CH2:17][CH2:18]1)=[O:10])#[N:2]

Participants

3

Reactant 2

HCID 211002572-Piperazin-1-yl-thiazole-5-carbonitrileHCID 211002975-Cyano-2-isopropoxybenzoic acid

Product 1

HCID 211002162-[4-(5-Cyano-2-isopropoxy-benzoyl)-piperazin-1-yl]-thiazole-5-carbonitrileYield 70%

Procedure

Prepared in analogy to example 1 (b) from 5-cyano-2-isopropoxy-benzoic acid (Example A28) and 2-piperazin-1-yl-thiazole-5-carbonitrile (Example 6(a)). The crude material was purified by chromatography (SiO2, ethyl acetate/heptane) to yield the title compound as a white solid (yield 70%). MS (m/e): 382.3 (M+H+, 100%).

Workup

  1. customThe crude material was purified by chromatography (SiO2, ethyl acetate/heptane)

Sources & evidence

ORD record
ord-3f6de8ea7ae84c2c93065c95340b95fe
Source dataset
uspto-grants-2007_05
Patent number
US07220744B2

Reaction notes

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