HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Piperazin-1-yl-thiazole-5-carbonitrile → 2-[4-(5-Cyano-2-isopropoxy-benzoyl)-piperazin-1-yl]-thiazole-5-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Piperazin-1-yl-thiazole-5-carbonitrile | HCID 21100257 | — |
| Reactant | 5-Cyano-2-isopropoxybenzoic acid | HCID 21100297 | — |
| Product | 2-[4-(5-Cyano-2-isopropoxy-benzoyl)-piperazin-1-yl]-thiazole-5-carbonitrile | HCID 21100216 | 70% |
Reaction Steps
Prepared in analogy to example 1 (b) from 5-cyano-2-isopropoxy-benzoic acid (Example A28) and 2-piperazin-1-yl-thiazole-5-carbonitrile (Example 6(a)). The crude material was purified by chromatography (SiO2, ethyl acetate/heptane) to yield the title compound as a white solid (yield 70%). MS (m/e): 382.3 (M+H+, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07220744B2 |
| Source dataset | uspto-grants-2007_05 |
| ORD ID | ord-3f6de8ea7ae84c2c93065c95340b95fe |
| Source note | uspto-grants-2007_05 |