2-Morpholino-5-nitrobenzoic acid → HCID 21100213, compound

HRID 1352411Notes

Reaction equation

HRID 1352411 reaction equation
[N:1]1([C:7]2[CH:15]=[CH:14][C:13]([N+:16]([O-:18])=[O:17])=[CH:12][C:8]=2[C:9]([OH:11])=O)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[N:19]1([C:25]2[S:26][C:27]([C:30]#[N:31])=[CH:28][N:29]=2)[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1>>[N:1]1([C:7]2[CH:15]=[CH:14][C:13]([N+:16]([O-:18])=[O:17])=[CH:12][C:8]=2[C:9]([N:22]2[CH2:23][CH2:24][N:19]([C:25]3[S:26][C:27]([C:30]#[N:31])=[CH:28][N:29]=3)[CH2:20][CH2:21]2)=[O:11])[CH2:2][CH2:3][O:4][CH2:5][CH2:6]1

Participants

3

Reactant 2

HCID 27257552-Morpholino-5-nitrobenzoic acidHCID 211002572-Piperazin-1-yl-thiazole-5-carbonitrile

Product 1

HCID 21100213HCID 21100213, compoundYield 24%

Procedure

Prepared in analogy to example 1 (b) from 2-morpholin-4-yl-5-nitro-benzoic acid (Example A27) and 2-piperazin-1-yl-thiazole-5-carbonitrile (Example 6(a)). The crude material was purified by chromatography (SiO2, methanol/dichloromethane) to yield the title compound as a yellow solid (yield 24%). MS (m/e): 429.5 (M+H+, 100%).

Workup

  1. customThe crude material was purified by chromatography (SiO2, methanol/dichloromethane)

Sources & evidence

ORD record
ord-fb9a43406dd246f5a9a140e70f8c10b3
Source dataset
uspto-grants-2007_05
Patent number
US07220744B2

Reaction notes

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